Hepatitis B

Hepatitis B Vaccine

Documentation of immunity is required by vaccination and a positive QUANTITATIVE Hepatitis B surface antibody titer (HBsAb or anti-HBs) and must be uploaded to the American Data Bank website. Reference ranges are indicated on the lab report for quantitative results.

Please indicate “in process” on documentation if you are just starting the series, and forward documentation of further doses and titer results as they become available to American Data Bank. It is recommended that students complete their 3-dose series prior to patient (or body fluid) contact in clinical settings.

Documentation required for each dose must include the date of vaccination and the name of the healthcare provider.

Documentation required for the titer must be a type written lab report which includes the collection datethe titer reference range, the titer result, and the name of the lab. No handwritten reports will be accepted. 

Note: The Hepisalav-B immunization series is not yet approved by our clinical site providers and will not be accepted.

Instructions For Health Care Providers

Initial series

  • The vaccination is given in a 3 dose series (upload documented proof of each dose to American Data Bank)
    • At least one month between dose one and two
    • At least five months between dose two and three
  • 6 – 8 weeks after the last dose in the series a QUANTITATIVE surface antibody titer (HBsAb or anti-HBs) is required. Reference ranges are indicated on the lab report for quantitative results.
    • Positive titer – you are done. Upload your results to American Data Bank.
    • Negative or equivocal titer
      • Upload your results to American Data Bank.
      • Sign the Hepatitis B Waiver 
        • Note: you cannot participate in the clinical setting without a positive titer or completing the Hepatitis B Waiver and uploading it to American Data Bank.

What to do if you don’t have documentation of the vaccination series

  • A series of QUANTITATIVE surface antibody titers (serologic testing) is necessary to determine if you are immune due to natural infection or currently or chronically infected. Reference ranges are indicated on the lab report for quantitative results.
    • anti-HBs or HBsAb (Hepatitis B surface antibody) – Immune to Hepatitis B due to immunization or natural infection.
    • anti-HBc or HBcAb (Hepatitis B core antibody) – currently or chronically infected.

Click here for a link to the CDC Serologic Testing page for Hepatitis B.

What to do after a negative or equivocal titer

  • Negative or equivocal titer – after you have had the Hepatitis B series (doses 1 -3). You must choose from the following two options.
    • You may receive a 4th dose (booster) followed by a QUANTITATIVE surface antibody titer (HBsAb or anti-HBs) 6 to 8 weeks later. If the titer is negative you must complete the Hepatitis B immunization series and a QUANTITATIVE surface antibody titer (HBsAb or anti-HBs) in 6 to 8 weeks. OR   
    • You may receive 3 additional doses of Hepatitis B vaccine, on the routine schedule, followed by a QUANTITATIVE surface antibody titer (HBsAb or anti-HBs) 6 to 8 weeks later. 
      • If your QUANTITATIVE surface antibody titer (HBsAb or anti-HBs) is still negative after two Hepatitis B immunization series you are considered a nonresponder. If you find yourself in this situation we encourage you to have a discussion with your healthcare provider regarding Hepatitis B exposure risk as a nurse. 
  • Negative or equivocal titer –  without documentation of the vaccination series. 
    • You are required to receive the initial series and titer (see above).